Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Author Frussa, R. Google Scholar
Goncalves, MTM Google Scholar
Andersen, M. L. Google Scholar
Araujo, N. P. de Google Scholar
Chinen, C. C. Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. the possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed. (C) 2004 Elsevier B.V. All rights reserved.
Keywords paradoxical sleep deprivation
behavioral sensitization
amphetamine
open-field behavior
conditioning
Language English
Date 2004-04-02
Published in Brain Research. Amsterdam: Elsevier B.V., v. 1003, n. 1-2, p. 188-193, 2004.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 188-193
Origin http://dx.doi.org/10.1016/j.brainres.2003.11.050
Access rights Closed access
Type Article
Web of Science ID WOS:000220830000023
URI http://repositorio.unifesp.br/handle/11600/27706

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