Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Autor Frussa, R. Google Scholar
Goncalves, MTM Google Scholar
Andersen, M. L. Google Scholar
Araujo, N. P. de Google Scholar
Chinen, C. C. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. the possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave paradoxical sleep deprivation
behavioral sensitization
amphetamine
open-field behavior
conditioning
Idioma Inglês
Data de publicação 2004-04-02
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1003, n. 1-2, p. 188-193, 2004.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 188-193
Fonte http://dx.doi.org/10.1016/j.brainres.2003.11.050
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220830000023
Endereço permanente http://repositorio.unifesp.br/handle/11600/27706

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