Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects

Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects

Author Gomes, L. F. Google Scholar
Alves, A. F. Google Scholar
Sevanian, A. Google Scholar
Peres, C. D. Google Scholar
Cendoroglo, M. S. Google Scholar
De Mello-Almada, C. Google Scholar
Quirino, L. M. Google Scholar
Ramos, L. R. Google Scholar
Junqueira, VBC Google Scholar
Institution Universidade de São Paulo (USP)
Univ So Calif
Universidade Federal de São Paulo (UNIFESP)
Abstract The levels of electronegative low-density lipoprotein (LDL-), LDL cholesterol oxidability, and plasma levels of molecular antioxidants and of beta(2)-glycoprotein I (beta(2) GPI) were studied in a group of 10 hypercholesterolemic (HC) and 10 normocholesterolemic (NC) elderly subjects. HC subjects showed significantly higher levels of cholesterol, LDL cholesterol, LDL-, and beta(2)GPI than NC, whereas high-density lipoprotein cholesterol and alpha-tocopherol levels were lower in HC as compared with NC subjects. Correlations among LDL- levels, LDL oxidation lag time, beta(2)GPI, and antioxidant plasma levels were studied in 100 HC elderly subjects. Lag time for in vitro LDL oxidation positively correlated with ubiquinol-10 levels (p = 0.008), but not with other antioxidants studied or beta(2)GPI. LDL- and alpha-tocopherol levels showed an inverse and significant correlation (p = 0.018). beta(2)GPI and LDL cholesterol levels were correlated (p = 0.001), whereas no significance was found between LDL- and beta(2) GPI levels (p = 0.057). the physiological significance of alpha-tocopherol and ubiquinol-10 levels on LDL- levels, and the presence of high levels of beta(2)-GPI, are discussed in terms of protective mechanisms operating during the overall atherosclerosis process.
Language English
Date 2004-04-01
Published in Antioxidants & Redox Signaling. Larchmont: Mary Ann Liebert Inc Publ, v. 6, n. 2, p. 237-244, 2004.
ISSN 1523-0864 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc Publ
Extent 237-244
Access rights Closed access
Type Article
Web of Science ID WOS:000220200800005

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