Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects

Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects

Autor Gomes, L. F. Google Scholar
Alves, A. F. Google Scholar
Sevanian, A. Google Scholar
Peres, C. D. Google Scholar
Cendoroglo, M. S. Google Scholar
De Mello-Almada, C. Google Scholar
Quirino, L. M. Google Scholar
Ramos, L. R. Google Scholar
Junqueira, VBC Google Scholar
Instituição Universidade de São Paulo (USP)
Univ So Calif
Universidade Federal de São Paulo (UNIFESP)
Resumo The levels of electronegative low-density lipoprotein (LDL-), LDL cholesterol oxidability, and plasma levels of molecular antioxidants and of beta(2)-glycoprotein I (beta(2) GPI) were studied in a group of 10 hypercholesterolemic (HC) and 10 normocholesterolemic (NC) elderly subjects. HC subjects showed significantly higher levels of cholesterol, LDL cholesterol, LDL-, and beta(2)GPI than NC, whereas high-density lipoprotein cholesterol and alpha-tocopherol levels were lower in HC as compared with NC subjects. Correlations among LDL- levels, LDL oxidation lag time, beta(2)GPI, and antioxidant plasma levels were studied in 100 HC elderly subjects. Lag time for in vitro LDL oxidation positively correlated with ubiquinol-10 levels (p = 0.008), but not with other antioxidants studied or beta(2)GPI. LDL- and alpha-tocopherol levels showed an inverse and significant correlation (p = 0.018). beta(2)GPI and LDL cholesterol levels were correlated (p = 0.001), whereas no significance was found between LDL- and beta(2) GPI levels (p = 0.057). the physiological significance of alpha-tocopherol and ubiquinol-10 levels on LDL- levels, and the presence of high levels of beta(2)-GPI, are discussed in terms of protective mechanisms operating during the overall atherosclerosis process.
Idioma Inglês
Data de publicação 2004-04-01
Publicado em Antioxidants & Redox Signaling. Larchmont: Mary Ann Liebert Inc Publ, v. 6, n. 2, p. 237-244, 2004.
ISSN 1523-0864 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc Publ
Extensão 237-244
Fonte http://dx.doi.org/10.1089/152308604322899305
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220200800005
Endereço permanente http://repositorio.unifesp.br/handle/11600/27702

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