Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection

Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection

Author Abreu-Silva, A. L. Google Scholar
Calabrese, K. S. Google Scholar
Mortara, R. A. Google Scholar
Tedesco, R. C. Google Scholar
Cardoso, F. O. Google Scholar
Carvalho, LOP Google Scholar
Da Costa, SCG Google Scholar
Institution Univ Estadual Maranhao
Fiocruz MS
Universidade Federal de São Paulo (UNIFESP)
Abstract Here we describe extracellular matrix alterations in footpad lesions and draining lymph nodes caused by Leishmania (L.) amazonensis in mouse strains with distinct susceptibilities to this parasite: BALB/c (susceptible), C57BL/6 (intermediate), and DBA/2 (resistant). Changes in ECM were observed mainly in BALB/c mice that, in general, presented tissue damage associated with high parasite burden. Under polarized light, Sirius Red revealed type I collagen that was predominant in the primary lesion in all strains studied at the early phase of infection, but gradually decreased and was replaced by abundant type III collagen fibre in chronic phase lesions. the presence of type III collagen seemed to provide support to inflammatory cells, mainly vacuolated and parasitized macrophages. Laminin expression was not altered during infection by L. (L.) amazonensis in any of the mouse strains studied. Furthermore, the decreased fibronectin expression, in all strains, in areas where amastigotes have been found, indicated that this decline was also not related to the genetic background.
Keywords Leishmania (L.) amazonensis
extracellular matrix
mouse strains
fibronectin
laminin
Language English
Date 2004-04-01
Published in Parasitology. New York: Cambridge Univ Press, v. 128, p. 385-390, 2004.
ISSN 0031-1820 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 385-390
Origin http://dx.doi.org/10.1017/S0031182003004621
Access rights Closed access
Type Article
Web of Science ID WOS:000221548700004
URI http://repositorio.unifesp.br/handle/11600/27696

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