Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats

Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats

Autor Andersen, M. L. Google Scholar
Santos, EHR Google Scholar
Seabra, M. D. Google Scholar
Silva, AAB da Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The extract of Harpagophytum procumbens, widely utilized ill Europe and, more recently, in other Countries. is traditionally indicated to treat inflammatory processes. Harpagophytum procumbens acts by way of interleukins and leukocyte migration to the painful and inflamed Joint area. Chemically, its secondary tuberous roots contains iridoid glycosides, harpagogide, procumbide, and harpagoside, as the active principle. the Purpose of the present Study was evaluate the therapeutic potential as anti-inflammatory and analgesic agent in rat model of Freund's adjuvant-induced arthritis both in the acute and chronic phases. the animals, were injected with Freund's adjuvant ill sub-plantar tissue of the right posterior paw and randomly assigned in acute (25, 50, or 100 mg/kg) or chronic (100 mg/kg) treatments with Harpagophytum procumbens solution test or vehicle. Then, submitted to behavioral test and assessment of body weight and right paw's measurements. the results show that Harpagophytum procumbens extract increased the animals 'latency of paws' withdrawal, indicating a protective effect against the pain induced by the thermal stimulus, both ill acute and chronic treatments. in addition to reduction in the right paw edema ill the experimental groups when compared to control group. Thus, the data showed anti-inflammatory and peripheral analgesic properties of Harpagophytum procumbens extract with all doses tested, thus confirming its indication for inflammatory processes. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave Harpagophytum procumbens
Freund's adjuvant-induced arthritis
anti-inflammatory properties
antinociceptive effects
Idioma Inglês
Data de publicação 2004-04-01
Publicado em Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 91, n. 2-3, p. 325-330, 2004.
ISSN 0378-8741 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 325-330
Fonte http://dx.doi.org/10.1016/j.jep.2004.01.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220728000020
Endereço permanente http://repositorio.unifesp.br/handle/11600/27694

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