Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: Macrophages from restrictive strains control parasitophorous vacuole maturation

Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: Macrophages from restrictive strains control parasitophorous vacuole maturation

Author Zamboni, Dario Simões Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetti phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.
Language English
Date 2004-04-01
Published in Infection and Immunity. Washington: Amer Soc Microbiology, v. 72, n. 4, p. 2395-2399, 2004.
ISSN 0019-9567 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2395-2399
Origin http://dx.doi.org/10.1128/IAI.72.4.2395-2399.2004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000220481600065
URI http://repositorio.unifesp.br/handle/11600/27685

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