Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury

Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury

Autor Mello, Marco Tulio de Autor UNIFESP Google Scholar
Esteves, A. M. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Study design: Randomized controlled trial of physical exercise and dopaminergic agonist in persons with spinal cord injury and periodic leg movement (PLM).Objective: the objective of the present study was to compare the effectiveness of physical exercise and of a dopaminergic agonist in reducing the frequency of PLM.Setting: Centro de Estudos em Psicobiologia e Exercicio. Universidade Federal de São Paulo, Brazil.Methods: A total of 13 volunteers (mean age: 31.6 +/- 8.3 years) received L-DOPA ( 200 mg) and benserazide ( 50 mg) 1 h before sleeping time for 30 days and were then submitted to a physical exercise program on a manual bicycle ergometer for 45 days ( 3 times a week).Results: Both L-DOPA administration (35.11 - 19.87 PLM/h, P<0.03) and physical exercise (35.11 - 18.53 PLM/h, P<0.012) significantly reduced PLM; however, no significant difference was observed between the two types of treatment.Conclusions: the two types of treatment were found to be effective in the reduction of PLM; however, physical exercise is indicated as the first treatment approach, while dopaminergic agonists or other drugs should only be recommended for patients who do not respond to this type of treatment.
Palavra-chave periodic limb movement (PLM)
physical exercise
L-DOPA
aerobic training
spinal
cord injury
sleep disorders
Idioma Inglês
Data de publicação 2004-04-01
Publicado em Spinal Cord. London: Nature Publishing Group, v. 42, n. 4, p. 218-221, 2004.
ISSN 1362-4393 (Sherpa/Romeo, fator de impacto)
Publicador Nature Publishing Group
Extensão 218-221
Fonte http://dx.doi.org/10.1038/sj.sc.3101575
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000220586600003
Endereço permanente http://repositorio.unifesp.br/handle/11600/27679

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