Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury

Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury

Author Mello, Marco Tulio de Autor UNIFESP Google Scholar
Esteves, A. M. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Study design: Randomized controlled trial of physical exercise and dopaminergic agonist in persons with spinal cord injury and periodic leg movement (PLM).Objective: the objective of the present study was to compare the effectiveness of physical exercise and of a dopaminergic agonist in reducing the frequency of PLM.Setting: Centro de Estudos em Psicobiologia e Exercicio. Universidade Federal de São Paulo, Brazil.Methods: A total of 13 volunteers (mean age: 31.6 +/- 8.3 years) received L-DOPA ( 200 mg) and benserazide ( 50 mg) 1 h before sleeping time for 30 days and were then submitted to a physical exercise program on a manual bicycle ergometer for 45 days ( 3 times a week).Results: Both L-DOPA administration (35.11 - 19.87 PLM/h, P<0.03) and physical exercise (35.11 - 18.53 PLM/h, P<0.012) significantly reduced PLM; however, no significant difference was observed between the two types of treatment.Conclusions: the two types of treatment were found to be effective in the reduction of PLM; however, physical exercise is indicated as the first treatment approach, while dopaminergic agonists or other drugs should only be recommended for patients who do not respond to this type of treatment.
Keywords periodic limb movement (PLM)
physical exercise
L-DOPA
aerobic training
spinal
cord injury
sleep disorders
Language English
Date 2004-04-01
Published in Spinal Cord. London: Nature Publishing Group, v. 42, n. 4, p. 218-221, 2004.
ISSN 1362-4393 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 218-221
Origin http://dx.doi.org/10.1038/sj.sc.3101575
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000220586600003
URI http://repositorio.unifesp.br/handle/11600/27679

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