Phosphorylation of translation initiation factor eIF2 alpha in the brain during pilocarpine-induced status epilepticus in mice

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dc.contributor.author Carnevalli, L. S.
dc.contributor.author Pereira, C. M.
dc.contributor.author Longo, B. M.
dc.contributor.author Jaqueta, C. B.
dc.contributor.author Avedissian, M.
dc.contributor.author Mello, LEAM
dc.contributor.author Castilho, B. A.
dc.date.accessioned 2016-01-24T12:37:03Z
dc.date.available 2016-01-24T12:37:03Z
dc.date.issued 2004-03-11
dc.identifier http://dx.doi.org/10.1016/j.neulet.2003.12.093
dc.identifier.citation Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 357, n. 3, p. 191-194, 2004.
dc.identifier.issn 0304-3940
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27673
dc.description.abstract In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine. eIF2alpha(P) immumoreactivity was detected in the hippocampal pyramidal layer CA1 and CA3, cortex layer V, thalamus and amygdala. After 2 It of recovery, there was a marked decrease in total brain eIF2alpha(P), with the cortex layer V showing the most pronounced loss of anti-eIF2alpha(P) labeling, whereas the CA1 subregion had a significant increase in eIF2alpha(P). These results indicate that inhibition of protein synthesis in experimental models of epilepsy might be due to low levels of eIF2-GTP caused by the phosphorylation of eIF2alpha, and suggest that translational control may contribute to cell fate in the affected areas. (C) 2003 Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 191-194
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuroscience Letters
dc.rights Acesso restrito
dc.subject eIF2 alpha phosphorylation en
dc.subject epilepsy en
dc.subject pilocarpine en
dc.subject translation initiation en
dc.title Phosphorylation of translation initiation factor eIF2 alpha in the brain during pilocarpine-induced status epilepticus in mice en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/j.neulet.2003.12.093
dc.description.source Web of Science
dc.identifier.wos WOS:000220125800009



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