Phosphorylation of translation initiation factor eIF2 alpha in the brain during pilocarpine-induced status epilepticus in mice

Phosphorylation of translation initiation factor eIF2 alpha in the brain during pilocarpine-induced status epilepticus in mice

Autor Carnevalli, L. S. Google Scholar
Pereira, C. M. Google Scholar
Longo, B. M. Google Scholar
Jaqueta, C. B. Google Scholar
Avedissian, M. Google Scholar
Mello, LEAM Google Scholar
Castilho, B. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine. eIF2alpha(P) immumoreactivity was detected in the hippocampal pyramidal layer CA1 and CA3, cortex layer V, thalamus and amygdala. After 2 It of recovery, there was a marked decrease in total brain eIF2alpha(P), with the cortex layer V showing the most pronounced loss of anti-eIF2alpha(P) labeling, whereas the CA1 subregion had a significant increase in eIF2alpha(P). These results indicate that inhibition of protein synthesis in experimental models of epilepsy might be due to low levels of eIF2-GTP caused by the phosphorylation of eIF2alpha, and suggest that translational control may contribute to cell fate in the affected areas. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave eIF2 alpha phosphorylation
epilepsy
pilocarpine
translation initiation
Idioma Inglês
Data de publicação 2004-03-11
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 357, n. 3, p. 191-194, 2004.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 191-194
Fonte http://dx.doi.org/10.1016/j.neulet.2003.12.093
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220125800009
Endereço permanente http://repositorio.unifesp.br/handle/11600/27673

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