Structure and expression of two kininogen genes in mice

Structure and expression of two kininogen genes in mice

Author Cardoso, C. C. Google Scholar
Garrett, T. Google Scholar
Cayla, C. Google Scholar
Meneton, P. Google Scholar
Pesquero, J. B. Google Scholar
Bader, M. Google Scholar
Institution Max Delbruck Ctr Mol Med
Albany State Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Kininogens serve dual functions by forming a scaffold for the assembly of the protein complex initiating the surfaceactivated blood coagulation cascade and as precursors for the kinin hormones. While rats have three kininogen genes, for mice, cattle, and humans only one gene has been described. Here, we present sequence and expression data of a second mouse kininogen gene. the two genes, kininogenI and kininogenII, are located in close proximity on chromosome 16 in a headtohead arrangement. in liver and kidney, both genes are expressed and for each gene three alternative splice variants are synthesized. Two of them are the expected high and low molecular weight isoforms known from all mammalian kininogens. However, for both genes also a third, hitherto unknown splice variant was detected which lacks part of the high molecular weight mRNA due to splicing from the low molecular weight donor site to alternative splice acceptor sites in exon 10. the physiological functions of the six kininogen isoforms predicted by these findings need to be determined.
Keywords alternative splicing
gene structure
kallikrein-kinin system
Language English
Date 2004-03-01
Published in Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 385, n. 3-4, p. 295-301, 2004.
ISSN 1431-6730 (Sherpa/Romeo, impact factor)
Publisher Walter de Gruyter & Co
Extent 295-301
Access rights Closed access
Type Article
Web of Science ID WOS:000220848000013

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