Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Author Bressan, R. A. Google Scholar
Jones, H. M. Google Scholar
Pilowsky, L. S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Psychiat
Abstract Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. the case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.
Keywords antipsychotic agents
atypical antipsychotic drugs
clozapine
dopamine
D-2 receptors
olanzapine
quetiapine
risperidone
tardive dyskinesia
Language English
Date 2004-03-01
Published in Journal of Psychopharmacology. London: Sage Publications Ltd, v. 18, n. 1, p. 124-127, 2004.
ISSN 0269-8811 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 124-127
Origin http://dx.doi.org/10.1177/0269881104040251
Access rights Closed access
Type Article
Web of Science ID WOS:000221158700021
URI http://repositorio.unifesp.br/handle/11600/27665

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