Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Autor Bressan, R. A. Google Scholar
Jones, H. M. Google Scholar
Pilowsky, L. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Inst Psychiat
Resumo Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. the case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.
Palavra-chave antipsychotic agents
atypical antipsychotic drugs
clozapine
dopamine
D-2 receptors
olanzapine
quetiapine
risperidone
tardive dyskinesia
Idioma Inglês
Data de publicação 2004-03-01
Publicado em Journal of Psychopharmacology. London: Sage Publications Ltd, v. 18, n. 1, p. 124-127, 2004.
ISSN 0269-8811 (Sherpa/Romeo, fator de impacto)
Publicador Sage Publications Ltd
Extensão 124-127
Fonte http://dx.doi.org/10.1177/0269881104040251
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221158700021
Endereço permanente http://repositorio.unifesp.br/handle/11600/27665

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