Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats

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dc.contributor.author Perry, J. C.
dc.contributor.author Vital, MABF
dc.contributor.author Frussa-Filho, R.
dc.contributor.author Tufik, S.
dc.contributor.author Palermo-Neto, J.
dc.date.accessioned 2016-01-24T12:37:01Z
dc.date.available 2016-01-24T12:37:01Z
dc.date.issued 2004-03-01
dc.identifier http://dx.doi.org/10.1016/S0924-977X(03)00074-9
dc.identifier.citation European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 14, n. 2, p. 127-133, 2004.
dc.identifier.issn 0924-977X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27657
dc.description.abstract In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. the animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. the results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1). in haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal. (C) 2003 Elsevier B.V./ECNP. All rights reserved. en
dc.format.extent 127-133
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Neuropsychopharmacology
dc.rights Acesso restrito
dc.subject haloperidol en
dc.subject GM(1) en
dc.subject monosialoganglioside en
dc.subject tardive dyskinesia en
dc.subject dopaminergic supersensitivity en
dc.title Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Fed Parana
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Univ Fed Parana, Sector Ciencias Biol, Dept Farmacol, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Vet Med, Appl Pharmacol & Toxicol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.identifier.doi 10.1016/S0924-977X(03)00074-9
dc.description.source Web of Science
dc.identifier.wos WOS:000189226800006



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