Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats

Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats

Author Perry, J. C. Google Scholar
Vital, MABF Google Scholar
Frussa-Filho, R. Google Scholar
Tufik, S. Google Scholar
Palermo-Neto, J. Google Scholar
Institution Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. the animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. the results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1). in haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal. (C) 2003 Elsevier B.V./ECNP. All rights reserved.
Keywords haloperidol
GM(1)
monosialoganglioside
tardive dyskinesia
dopaminergic supersensitivity
Language English
Date 2004-03-01
Published in European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 14, n. 2, p. 127-133, 2004.
ISSN 0924-977X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 127-133
Origin http://dx.doi.org/10.1016/S0924-977X(03)00074-9
Access rights Closed access
Type Article
Web of Science ID WOS:000189226800006
URI http://repositorio.unifesp.br/handle/11600/27657

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