Author |
Perry, J. C.
![]() Vital, MABF ![]() Frussa-Filho, R. ![]() Tufik, S. ![]() Palermo-Neto, J. ![]() |
Institution | Univ Fed Parana Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
Abstract | In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. the animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. the results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1). in haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal. (C) 2003 Elsevier B.V./ECNP. All rights reserved. |
Keywords |
haloperidol
GM(1) monosialoganglioside tardive dyskinesia dopaminergic supersensitivity |
Language | English |
Date | 2004-03-01 |
Published in | European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 14, n. 2, p. 127-133, 2004. |
ISSN | 0924-977X (Sherpa/Romeo, impact factor) |
Publisher | Elsevier B.V. |
Extent | 127-133 |
Origin |
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Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000189226800006 |
URI | http://repositorio.unifesp.br/handle/11600/27657 |
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