Role of dobutamine-atropine stress echocardiography in prognostic evaluation of 300 women

Role of dobutamine-atropine stress echocardiography in prognostic evaluation of 300 women

Author Cordovil, Adriana Autor UNIFESP Google Scholar
Junior, W. M. Google Scholar
Andrade, J. L. Google Scholar
Campos, O. Google Scholar
Moises, V. A. Google Scholar
Adan, M. Google Scholar
Machado, C. V. Google Scholar
Arruda, A. M. Google Scholar
Paiva, M. G. Google Scholar
Carvalho, A. C. Google Scholar
Paola, A. A. de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Dobutamine-atropine stress echocardiography (DASE) is a safe and accurate method to diagnose coronary artery disease (CAD), and can identify individuals at high risk for cardiac events such as myocardial infarction and cardiac-related death. the literature is limited regarding the prognostic value of DASE in women. Objective: the objective was to determine the prognostic value of DASE in 300 women with known or suspected CAD. Results: the 300 women underwent DASE and were followed up for 65 months (mean: 27 months). Ninety-five women had positive tests and 205 had negative tests. We demonstrated that women with negative tests had a 94% hard-event-free survival rate at follow-up (myocardial infarction and death), and in those with positive tests the event-free survival rate was 27% (P = 0.0003). the difference between women with positive and negative tests was also significant when minor events and total events were considered. Women with positive tests had 16.7 times more chance of having events than women with negative tests. Furthermore, women with positive tests but without cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.24 0.16) had less ischemic myocardium than women with positive tests and cardiac events at follow-up (mean of peak WMSI - rest WMSI = 0.34 +/- 0.26)(P < 0.04). Conclusion: Dobutamine-atropine stress echocardiography has good prognostic value for cardiac events in women. Women with negative tests have low probability for follow-up infarction or death. Women with positive tests and higher severity of induced ischemia have the highest incidence of cardiac events.
Keywords dobutamine
Language English
Date 2004-02-01
Published in Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. Malden: Blackwell Futura Publishing, Inc, v. 21, n. 2, p. 113-118, 2004.
ISSN 0742-2822 (Sherpa/Romeo, impact factor)
Publisher Blackwell Futura Publishing, Inc
Extent 113-118
Access rights Closed access
Type Article
Web of Science ID WOS:000189360700002

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