Effects of intravitreal indocyanine green injection in rabbits

Effects of intravitreal indocyanine green injection in rabbits

Author Maia, M. Google Scholar
Margalit, E. Google Scholar
Lakhanpal, R. Google Scholar
Tso, MOM Google Scholar
Grebe, R. Google Scholar
Torres, G. Google Scholar
Eong, KGA Google Scholar
Farah, M. E. Google Scholar
Fujii, G. Y. Google Scholar
Weiland, J. Google Scholar
De Juan, E. Google Scholar
D'Anna, S. A. Google Scholar
Humayun, M. S. Google Scholar
Institution Univ So Calif
Johns Hopkins Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To report the clinical, electrophysiologic, and histologic findings of different concentrations of indocyanine green (ICG) injected into the vitreous cavity of rabbit eyes.Methods: Forty-two rabbits underwent intravitreal injection of 0.1 mL of ICG in three different concentrations: 0.5 mg/mL (250 mOsm), 5 mg/mL (270 mOsm), and 25 mg/mL (170 mOsm). Fellow eyes were injected with 0.1 mL of balanced salt solution. Biomicroscopy, ophthalmoscopy, electroretinography, fluorescein angiography, and histologic evaluation were performed.Results: Eyes injected with 0.5 mg/mL of ICG showed b-wave latency delay on the first day after injection. Eyes injected with 5 mg/mL of ICG showed b-wave latency delay and decreased b-wave amplitude on the first and seventh days after injection; delayed a-wave latency on the first day after injection was also observed. Eyes injected with 25 mg/mL of ICG showed b- and a-wave amplitude and latency abnormalities during the entire followup. Direct correlation of increasing retinal edema proportional to the progressively increasing ICG concentrations was shown on histologic evaluation.Conclusion: Intravitreal ICG injection in rabbit eyes may impair retinal function and morphology proportional to the progressively increasing ICG dosages.
Language English
Date 2004-02-01
Published in Retina-the Journal of Retinal and Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 24, n. 1, p. 69-79, 2004.
ISSN 0275-004X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 69-79
Origin http://dx.doi.org/10.1097/00006982-200402000-00011
Access rights Closed access
Type Article
Web of Science ID WOS:000189234200011
URI http://repositorio.unifesp.br/handle/11600/27622

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