Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin

Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin

Author Maciel, Gustavo Arantes Rosa Autor UNIFESP Google Scholar
Soares Junior, José Autor UNIFESP Google Scholar
Motta, Eduardo Leme Alves da Autor UNIFESP Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To determine the clinical, hormonal, and biochemical effects of metformin therapy in obese and nonobese patients with polycystic ovary syndrome (PCOS).Design: Controlled clinical study.Setting: Department of Gynecology of Federal University of São Paulo, São Paulo, Brazil.Patient(s): Twenty-nine patients with PCOS.Intervention(s): Patients were treated with 500 mg of p.o. metformin t.i.d. for 6 months.Main Outcome Measure(s): Clinical data as well as serum concentrations of sex steroids, sex hormone-binding globulin (SHBG), gonadotropins, leptin, GH, lipids, insulin, and glucose levels were assessed before and after treatment.Result(s): in the metformin group of nonobese patients, the mean fasting serum insulin concentration decreased from a pretreatment value of 12.1 +/- 2.4 to 6.3 +/- 0.6 muU/mL after treatment, and the area under the curve of insulin decreased from 5,189.1 +/- 517.4 to 3,035.6 +/- 208.9 muU/mL per minute. Also in the metformin group of nonobese patients, the mean basal serum total testosterone, free testosterone, and androstenedione concentrations decreased by 38%, 58%, and 30%, respectively. in the obese patients treated with metformin, only free testosterone showed a statistically significant decrease (1.7 +/- 0.2).Conclusion(s): Our data suggest that nonobese patients respond better than obese patients to a 1.5 g/day metformin regimen. (C)2004 by American Society for Reproductive Medicine.
Keywords polycystic ovary syndrome
metformin
insulin resistance
Language English
Date 2004-02-01
Published in Fertility and Sterility. New York: Elsevier B.V., v. 81, n. 2, p. 355-360, 2004.
ISSN 0015-0282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 355-360
Origin http://dx.doi.org/10.1016/j.fertnstert.2003.08.012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000188970500023
URI http://repositorio.unifesp.br/handle/11600/27591

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