Modulation of peripheral blood T-lymphocytes in kidney transplant recipients treated with low dose OKT3 therapy

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dc.contributor.author Galante, N. Z.
dc.contributor.author Camara, NOS
dc.contributor.author Kall s, E. G.
dc.contributor.author Salomão, Reinaldo [UNIFESP]
dc.contributor.author Pacheco-Silva, A.
dc.date.accessioned 2016-01-24T12:34:15Z
dc.date.available 2016-01-24T12:34:15Z
dc.date.issued 2004-01-30
dc.identifier http://dx.doi.org/10.1016/j.imlet.2003.10.008
dc.identifier.citation Immunology Letters. Amsterdam: Elsevier B.V., v. 91, n. 1, p. 75-77, 2004.
dc.identifier.issn 0165-2478
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27587
dc.description.abstract The immunosuppressive effect of OKT3 depends upon both T cell depletion and antigenic modulation of CD3 complex. To establish the effect of low doses of OKT3 on peripheral T lymphocytes, we analyzed 47 kidney transplant recipients receiving OKT3 for the first time. OKT3 was used as rescue therapy in 39 patients and as part of induction protocols in 8. the mean age of patients was 39 1 10 years, 30 were females and 9 were re-transplants. Half of them (51.1%) received kidney from cadaver donors. Among those receiving OKT3 as rescue therapy, 82% recovered graft function, including patients with severe BANFF-graded rejections. After the first dose of OKT3, it a pronounced T cell depletion was observed followed by an increase in CD4 and CD8 expression in CD3 negative T cells, supporting the idea that T cell modulation was present. in conclusion, low dose OKT3 was effective in treating severe allograft rejection by inducing a sustained TCR/CD3 down modulation without long-lasting T cell depletion. (C) 2003 Elsevier B.V. All rights reserved. en
dc.format.extent 75-77
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Immunology Letters
dc.rights Acesso restrito
dc.subject T lymphocytes en
dc.subject OKT3 en
dc.subject T-cell activation en
dc.subject kidney transplantation en
dc.title Modulation of peripheral blood T-lymphocytes in kidney transplant recipients treated with low dose OKT3 therapy en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Lab Imunol Clin & Expt, Disciplina Nefrol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Lab Imunol, Disciplina Doencas Infecciosas & Parasitarias, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Lab Imunol Clin & Expt, Disciplina Nefrol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Lab Imunol, Disciplina Doencas Infecciosas & Parasitarias, São Paulo, Brazil
dc.identifier.doi 10.1016/j.imlet.2003.10.008
dc.description.source Web of Science
dc.identifier.wos WOS:000188972700012



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