Effects of estrogen on muscarinic acetylcholine receptors in the rat hippocampus

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dc.contributor.author Cardoso, C. C.
dc.contributor.author Pereira, RTS
dc.contributor.author Koyama, C. A.
dc.contributor.author Porto, C. S.
dc.contributor.author Abdalla, FMF
dc.date.accessioned 2016-01-24T12:34:14Z
dc.date.available 2016-01-24T12:34:14Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1159/000084202
dc.identifier.citation Neuroendocrinology. Basel: Karger, v. 80, n. 6, p. 379-386, 2004.
dc.identifier.issn 0028-3835
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27574
dc.description.abstract The aim of the present study was to investigate whether different estrogen manipulations have effects on the expression of muscarinic acetylcholine receptors ( mAChRs) in the adult female rat hippocampus. Hippocampus was obtained from rats in proestrus ( control), ovariectomized for 2, 10 and 15 days, ovariectomized for 15 days and treated with 17 beta-estradiol for 7 days, and treated with 17 beta-estradiol immediately after ovariectomy for 21 days. Rats' estrogen status was monitored by measuring estradiol plasma levels and uterus relative weight. [ 3 H] quinuclidinyl benzilate ([H-3] QNB) binding studies indicated that ovariectomy time-dependently increases the number of mAChRs in hippocampus when compared to those obtained from control rats. Estradiol treatments for 21 days avoid the effect of ovariectomy. However, the estradiol treatments for 7 days after 15 days of ovariectomy slightly change the number of mAChRs. in conclusion, these results showed that ovariectomy time-dependently increases mAChRs number in the rat hippocampus. in addition, these data suggest that treatment with estradiol initiated within a specific period of time after the loss of ovarian function may be effective at preventing specific effects of hormone deprivation on hippocampus. en
dc.format.extent 379-386
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Neuroendocrinology
dc.rights Acesso restrito
dc.subject acetylcholine receptors en
dc.subject hippocampus en
dc.subject ovariectomy en
dc.subject gonadal steroids en
dc.title Effects of estrogen on muscarinic acetylcholine receptors in the rat hippocampus en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Inst Butantan, Pharmacol Lab, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Inst Butantan, Pharmacol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, São Paulo, Brazil
dc.identifier.doi 10.1159/000084202
dc.description.source Web of Science
dc.identifier.wos WOS:000229431300004



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