Anti-N-like and anti-form red cell antibodies in chronic hemodialysis patients

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dc.contributor.author Fonseca, HEM
dc.contributor.author Chiba, A. K.
dc.contributor.author Junior, A. F.
dc.contributor.author Draibe, S. A.
dc.contributor.author Bordin, J. O.
dc.date.accessioned 2016-01-24T12:34:13Z
dc.date.available 2016-01-24T12:34:13Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1081/JDI-200031759
dc.identifier.citation Renal Failure. New York: Marcel Dekker Inc, v. 26, n. 5, p. 553-556, 2004.
dc.identifier.issn 0886-022X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27559
dc.description.abstract Allogeneic red blood cell (RBC) transfusions and the use of reusable dialyzers sterilized with formaldehyde can lead to RBC alloimmunization in chronic hemodialysis patients. the formed RBC alloantibodies have been implicated in immediate kidney allograft failure and decreased RBC survival observed in these patients. Using indirect antiglobulin test, direct antiglobulin test (DAT), and direct Polibrene(R) test (DPT), we detected an RBC alloimmunization rate of 17.2% (11/64) in transfused hemodialysis patients, and found the presence of anti-N-like and anti-Form antibodies in 5 (5.7%) and 53 (60.9%) individuals, respectively. the sensitivity rate of the DPT was significantly higher than that of the DAT in detecting anti-Form, but the DAT showed a higher specificity rate compared with the DPT. We conclude that patients treated with reusable dialyzers sterilized with formaldehyde may develop specific RBC alloantibodies that could increase the potential risk of hemolysis, decrease survival of RBCs, and increase the need of blood supply. en
dc.format.extent 553-556
dc.language.iso eng
dc.publisher Marcel Dekker Inc
dc.relation.ispartof Renal Failure
dc.rights Acesso restrito
dc.subject red cell antibodies en
dc.subject hemodialysis en
dc.subject immune hemolysis en
dc.subject renal failure en
dc.subject formaldehyde en
dc.title Anti-N-like and anti-form red cell antibodies in chronic hemodialysis patients en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapie, BR-04023092 São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Nefrol, BR-04023092 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapie, BR-04023092 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Nefrol, BR-04023092 São Paulo, SP, Brazil
dc.identifier.doi 10.1081/JDI-200031759
dc.description.source Web of Science
dc.identifier.wos WOS:000224501400011



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