Anti-N-like and anti-form red cell antibodies in chronic hemodialysis patients

Anti-N-like and anti-form red cell antibodies in chronic hemodialysis patients

Author Fonseca, HEM Google Scholar
Chiba, A. K. Google Scholar
Junior, A. F. Google Scholar
Draibe, S. A. Google Scholar
Bordin, J. O. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Allogeneic red blood cell (RBC) transfusions and the use of reusable dialyzers sterilized with formaldehyde can lead to RBC alloimmunization in chronic hemodialysis patients. the formed RBC alloantibodies have been implicated in immediate kidney allograft failure and decreased RBC survival observed in these patients. Using indirect antiglobulin test, direct antiglobulin test (DAT), and direct Polibrene(R) test (DPT), we detected an RBC alloimmunization rate of 17.2% (11/64) in transfused hemodialysis patients, and found the presence of anti-N-like and anti-Form antibodies in 5 (5.7%) and 53 (60.9%) individuals, respectively. the sensitivity rate of the DPT was significantly higher than that of the DAT in detecting anti-Form, but the DAT showed a higher specificity rate compared with the DPT. We conclude that patients treated with reusable dialyzers sterilized with formaldehyde may develop specific RBC alloantibodies that could increase the potential risk of hemolysis, decrease survival of RBCs, and increase the need of blood supply.
Keywords red cell antibodies
hemodialysis
immune hemolysis
renal failure
formaldehyde
Language English
Date 2004-01-01
Published in Renal Failure. New York: Marcel Dekker Inc, v. 26, n. 5, p. 553-556, 2004.
ISSN 0886-022X (Sherpa/Romeo, impact factor)
Publisher Marcel Dekker Inc
Extent 553-556
Origin http://dx.doi.org/10.1081/JDI-200031759
Access rights Closed access
Type Article
Web of Science ID WOS:000224501400011
URI http://repositorio.unifesp.br/handle/11600/27559

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