Preparation and evaluation of two Re-188-radiopharmaceuticals for endovascular irradiation

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dc.contributor.author Faintuch, B. L.
dc.contributor.author Faintuch, S.
dc.contributor.author Muramoto, E.
dc.date.accessioned 2016-01-24T12:34:13Z
dc.date.available 2016-01-24T12:34:13Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1023/B:JRNC.0000027110.04651.ec
dc.identifier.citation Journal of Radioanalytical and Nuclear Chemistry. Dordrecht: Kluwer Academic Publ, v. 260, n. 2, p. 363-368, 2004.
dc.identifier.issn 0236-5731
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27553
dc.description.abstract Procedures for complexing DTPA with Re-188 from a ready kit and by conventional manipulation were elaborated and the study of the stability and biodistribution of Re-188 perrhenate and Re-188-DTPA were performed. Best labeling was achieved using DTPA (38 mM) with 2 mg/ml of SnCl2.2H(2)O. the radiochemical purity was 95.9 +/- 2.9%. the complex was stable for 24 hours when ascorbic acid was used. Greatest uptake of Re-188-DTPA was by kidneys (19.3 +/- 2.1%ID/g) and for Re-188-perrhenate by stomach (21.3 +/- 2.8%ID/g). in conclusion, a kit of freeze-dried DTPA was developed. Organ damage is unlikely by virtue of its rapid urinary excretion. en
dc.format.extent 363-368
dc.language.iso eng
dc.publisher Kluwer Academic Publ
dc.relation.ispartof Journal of Radioanalytical and Nuclear Chemistry
dc.rights Acesso restrito
dc.title Preparation and evaluation of two Re-188-radiopharmaceuticals for endovascular irradiation en
dc.type Artigo
dc.contributor.institution IPEN
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation IPEN, CNEN, Radiopharm Ctr, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Radiol, São Paulo, Brazil
dc.identifier.doi 10.1023/B:JRNC.0000027110.04651.ec
dc.description.source Web of Science
dc.identifier.wos WOS:000221331000020



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