Preparation and evaluation of two Re-188-radiopharmaceuticals for endovascular irradiation

Preparation and evaluation of two Re-188-radiopharmaceuticals for endovascular irradiation

Author Faintuch, B. L. Google Scholar
Faintuch, S. Google Scholar
Muramoto, E. Google Scholar
Institution IPEN
Universidade Federal de São Paulo (UNIFESP)
Abstract Procedures for complexing DTPA with Re-188 from a ready kit and by conventional manipulation were elaborated and the study of the stability and biodistribution of Re-188 perrhenate and Re-188-DTPA were performed. Best labeling was achieved using DTPA (38 mM) with 2 mg/ml of SnCl2.2H(2)O. the radiochemical purity was 95.9 +/- 2.9%. the complex was stable for 24 hours when ascorbic acid was used. Greatest uptake of Re-188-DTPA was by kidneys (19.3 +/- 2.1%ID/g) and for Re-188-perrhenate by stomach (21.3 +/- 2.8%ID/g). in conclusion, a kit of freeze-dried DTPA was developed. Organ damage is unlikely by virtue of its rapid urinary excretion.
Language English
Date 2004-01-01
Published in Journal of Radioanalytical and Nuclear Chemistry. Dordrecht: Kluwer Academic Publ, v. 260, n. 2, p. 363-368, 2004.
ISSN 0236-5731 (Sherpa/Romeo, impact factor)
Publisher Kluwer Academic Publ
Extent 363-368
Origin http://dx.doi.org/10.1023/B:JRNC.0000027110.04651.ec
Access rights Closed access
Type Article
Web of Science ID WOS:000221331000020
URI http://repositorio.unifesp.br/handle/11600/27553

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