The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

Autor Dale, C. S. Google Scholar
Goncalves, LRC Google Scholar
Juliano, L. Google Scholar
Juliano, M. A. Google Scholar
Silva, AMM da Google Scholar
Giorgi, R. Google Scholar
Instituição Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.
Assunto hyperalgesia
edema
jararhagin
papain
MRP-14
S100A9
Idioma Inglês
Data 2004-01-01
Publicado em Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 81-89
Fonte http://dx.doi.org/10.1016/j.peptides.2003.12.008
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220267900011
URI http://repositorio.unifesp.br/handle/11600/27547

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