Normal pituitary volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study

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dc.contributor.author Chen, H. H.
dc.contributor.author Nicoletti, M.
dc.contributor.author Sanches, M.
dc.contributor.author Hatch, J. P.
dc.contributor.author Sassi, R. B.
dc.contributor.author Axelson, D.
dc.contributor.author Brambilla, P.
dc.contributor.author Keshavan, M. S.
dc.contributor.author Ryan, N.
dc.contributor.author Birmaher, B.
dc.contributor.author Soares, J. C.
dc.date.accessioned 2016-01-24T12:34:10Z
dc.date.available 2016-01-24T12:34:10Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1002/da.20044
dc.identifier.citation Depression and Anxiety. Hoboken: Wiley-liss, v. 20, n. 4, p. 182-186, 2004.
dc.identifier.issn 1091-4269
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27532
dc.description.abstract The volume of the pituitary gland in adults with bipolar disorder has previously been reported to be smaller than that of healthy controls. Such abnormalities would be consistent with the HPA dysfunction reported in this illness. We conducted a study of children and adolescents with bipolar disorder to determine whether size abnormalities in the pituitary gland are already present early in illness course. Magnetic resonance imaging (MRI) morphometric analysis of the pituitary gland was carried out in 16 DSM-IV children and adolescents with bipolar disorder (mean age +/- sd = 15.5 +/- 3.4 years) and 21 healthy controls (mean age +/- sd = 16.9 +/- 3. 8 years). Subjects underwent a 1.5 T MRI, with 3-D Spoiled Gradient Recalled (SPGR) acquisition. There was no statistically significant difference between pituitary gland volumes of bipolar patients compared to healthy controls (ANCOVA, age, gender, and ICV as covariates; F = 1.77, df = 1,32, P = .19). There was a statistically significant direct relationship between age and pituitary gland volume in both groups (r =. 59, df = 17, P = .007 for healthy controls; r = .61, df = 12, P = .008 for bipolar patients). No evidence of size abnormalities in the pituitary gland was found in child and adolescent bipolar patients, contrary to reports involving adult bipolar patients. This suggests that anatomical abnormalities in this structure may develop later in illness course as a result of continued HPA dysfunction. Depression and Anxiety 20:182-186, 2004. (C) 2005 Wiley-Liss, Inc. en
dc.format.extent 182-186
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Depression and Anxiety
dc.rights Acesso restrito
dc.subject magnetic resonance imaging en
dc.subject bipolar disorder en
dc.subject pituitary en
dc.subject adolescents en
dc.title Normal pituitary volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Univ Texas
dc.contributor.institution Audie L Murphy Div
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Univ Pittsburgh
dc.contributor.institution Univ Udine
dc.description.affiliation Univ Texas, Hlth Sci Ctr, Div Mood & Anxiety Disorders, Dept Psychait, San Antonio, TX 78229 USA
dc.description.affiliation Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX USA
dc.description.affiliation Audie L Murphy Div, S Texas Vet Hlth Care Syst, San Antonio, TX USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ Pittsburgh, Ctr Med, Dept Psychiat, Pittsburgh, PA USA
dc.description.affiliation Univ Udine, Sect Psychiat, Dept Pathol & Expt & Clin Med, Udine, Italy
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1002/da.20044
dc.description.source Web of Science
dc.identifier.wos WOS:000226613900004



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