Proteinase inhibitors in Brazilian leguminosae

Proteinase inhibitors in Brazilian leguminosae

Autor Sampaio, Claudio Augusto Machado Autor UNIFESP Google Scholar
Oliva, Maria Luiza Vilela Autor UNIFESP Google Scholar
Tanaka, Aparecida Sadae Autor UNIFESP Google Scholar
Sampaio, Misako Uemura Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFMS Instituto de Química Departamento de Química
Resumo Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting factors. The inhibitors were purified from Enterolobium contortisiliquum (Mr=23,000), Torresea cearensis (Mr = 13,000), Bauhinia pentandra (Mr = 20,000) and Bauhinia bauhinioides (Mr = 20,000). E. contortisiliquum inhibitor inactivates all three enzymes, whereas the T. cearensis inhibitor inactivates trypsin and Factor XSSa, but does nor affect plasma kallikrein; both Bauhinia inhibitors, on the other hand, inactivate trypsin and plasma kallikrein but only the Bpentandra inhibitor affects Factor XIIa. Ki values were calculated between 10 [raised to the power of] -7 and 10 [raised to the power of] -8 M.
Palavra-chave Bauhinia bauhinioides
Bauhinia pentandra
coagulation
Enterolobium contortisiliquum
proteinase inhibitor
Torresea cearensis
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 207-209, 1991.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 207-209
Fonte http://dx.doi.org/10.1590/S0074-02761991000600047
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1991GN58900047
SciELO S0074-02761991000600047 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/275

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