Bone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in São Paulo, Brazil

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dc.contributor.author Sdepanian, Vera Lucia [UNIFESP]
dc.contributor.author Carvalho, Cecília Noronha de Miranda [UNIFESP]
dc.contributor.author Morais, Mauro Batista de [UNIFESP]
dc.contributor.author Colugnati, Fernando Antonio Basile [UNIFESP]
dc.contributor.author Fagundes Neto, Ulysses [UNIFESP]
dc.date.accessioned 2016-01-24T12:34:06Z
dc.date.available 2016-01-24T12:34:06Z
dc.date.issued 2003-11-01
dc.identifier http://dx.doi.org/10.1097/00005176-200311000-00013
dc.identifier.citation Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 37, n. 5, p. 571-576, 2003.
dc.identifier.issn 0277-2116
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27455
dc.description.abstract Background: To compare bone mineral density (BMD) in children and adolescents with celiac disease (CD) and control subjects and to evaluate diet adequacy and calcium metabolism in patients with CD.Methods: Thirty patients with asymptomatic CD (17 children, 13 adolescents). on a gluten-free diet, and 23 healthy subjects were studied. BMD of the lumbar spine (dual energy x-ray absorptiometry) was performed on all patients and control subjects. in patients. food diaries for nine nonconsecutive days were obtained and analyzed. in patients, laboratory tests pertaining to calcium balance were obtained.Results: the mean weight and height of the adolescents with CD Were lower than those of control subjects (weight: 45.8 +/- 10.5 kg v 55.3 +/- 10.5 kg, P = 0.037; height: 153.0 +/- 11.0 cm v 167 +/- 12.0 cm. P = 0.007). the mean BMD in adolescents With CD was significantly lower than that of the control subjects (0.917 +/- 0.116 g/cm(2) v 1.060 +/- 0.158 g/cm(2), P = 0.015), whereas no significant difference was found between children with CD and control subjects (P = 0.595). A multiple-regression model shows that increases in BMD relative to height were lower in adolescents with CD than in control subjects. the proportion of adolescents who had started a gluten-free diet after 2 years of age was higher than that of children with CD (P < 0.001). High percentages of magnesium, calcium, and phosphorous deficiencies were present in CD patients' diets. the serum levels of ionized and total calcium and parathormone were normal.Conclusions: the BMD of adolescents with CD was lower than that of the control subjects, whereas no difference was found between the BMD of children with CD and that of control subjects. en
dc.format.extent 571-576
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal of Pediatric Gastroenterology and Nutrition
dc.rights Acesso aberto
dc.subject celiac disease en
dc.subject bone mineral density en
dc.subject gluten-free diet en
dc.subject nutritional status en
dc.subject children en
dc.subject adolescents en
dc.title Bone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in São Paulo, Brazil en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Pediat Gastroenterol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Pediat Gastroenterol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.identifier.doi 10.1097/00005176-200311000-00013
dc.description.source Web of Science
dc.identifier.wos WOS:000186329000012



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