Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression

Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression

Autor Ribas, C. Autor UNIFESP Google Scholar
Colleoni, Gisele Wally Braga Autor UNIFESP Google Scholar
Almeida, M.s.s. Autor UNIFESP Google Scholar
Aguiar, K.c.c. Autor UNIFESP Google Scholar
Silva, M.r.r. Autor UNIFESP Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The biologic basis of the negative prognosis of plasmablastic myeloma is not fully understood. To determine whether histologically aggressive multiple myeloma (MM) is associated with a more angiogenic marrow environment, bone marrow samples from 50 recently diagnosed MM patients were evaluated. Twelve percent (6/50) of patients presented plasmablastic MM, and this feature correlated with moderate/strong intensity of vascular endothelial growth factor staining of plasma cells (P = 0.036). Although plasmablastic MM was not associated with increasing of microvessel density, this new evidence of increased expression of vascular endothelial growth factor on plasmablasts suggests that the adverse prognosis conferred by plasmablastic disease may be due, at least in part, to secretion of this angiogenic cytokine, also suggesting that the subset of MM patients with plasmablastic features may derive particular benefit from antiangiogenic therapies.
Palavra-chave Multiple myeloma
Angiogenesis
Vascular endothelial growth factor
Idioma Inglês
Data de publicação 2005-11-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 11, p. 1609-1613, 2005.
ISSN 0100-879X (Sherpa/Romeo)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1609-1613
Fonte http://dx.doi.org/10.1590/S0100-879X2005001100007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0100-879X2005001100007 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2745

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