Comparative activity and spectrum of broad-spectrum beta-lactams (cefepime, ceftazidime, ceftriaxone, piperacillin/tazobactam) tested against 12,295 staphylococci and streptococci: report from the SENTRY antimicrobial surveillance program (North America: 2001-2002)

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dc.contributor.author Fritsche, T. R.
dc.contributor.author Sader, H. S.
dc.contributor.author Jones, R. N.
dc.date.accessioned 2016-01-24T12:34:04Z
dc.date.available 2016-01-24T12:34:04Z
dc.date.issued 2003-10-01
dc.identifier http://dx.doi.org/10.1016/S0732-8893(03)00114-7
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 47, n. 2, p. 435-440, 2003.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27429
dc.description.abstract A contemporary collection of 12,295 North American isolates (2001-2002) consisting of Staphylococcus aureus (50%), coagulase-negative staphylococci (12%), Streptococcus pneumoniae (24%), beta-hemolytic streptococci (12%), and viridans-group streptococci (2%) were tested against broad-spectrum beta-lactams (cefepime, ceftazidime, ceftriaxone, imipenem, piperacillin/tazobactam) and comparator agents using a reference broth microdilution method to determine their continued effectiveness for empiric antimicrobial therapy. All isolates were very susceptible to vancomycin, linezolid and quinupristin/dalfopristin (>98%). Oxacillin-susceptible staphylococci were also highly susceptible to the tested beta-lactams (>98%) with the exception of ceftazidime (93%). beta-hemolytic streptococci were exquisitely susceptible (>99%) to penicillin and all other agents except for clindamycin (94%) and erythromycin (81%). Viridans group streptococci were routinely less susceptible than were other streptococci. S. pneumoniae remained susceptible to most agents (>91%) with the exceptions of erythromycin (74%) and penicillin (69%). Among beta-lactams tested against S. pneumoniae, ceftriaxone and cefepime continued to be very active against penicillin-susceptible (>99%) and intermediate (>98%) strains, but less active (80% and 82%, respectively) against penicillin-resistant isolates. These findings confirm that the newer cephalosporins (cefepime and ceftriaxone) among broad-spectrum beta-lactam agents have a spectrum of activity that remains comprehensive for the commonly isolated Gram-positive pathogens. (C) 2003 Elsevier Inc. All rights reserved. en
dc.format.extent 435-440
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.title Comparative activity and spectrum of broad-spectrum beta-lactams (cefepime, ceftazidime, ceftriaxone, piperacillin/tazobactam) tested against 12,295 staphylococci and streptococci: report from the SENTRY antimicrobial surveillance program (North America: 2001-2002) en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution JONES Grp
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Tufts Univ
dc.description.affiliation JONES Grp, JMI Labs, N Liberty, IA USA
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Tufts Univ, Sch Med, Boston, MA 02111 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1016/S0732-8893(03)00114-7
dc.description.source Web of Science
dc.identifier.wos WOS:000185924600009



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