Importance of combined-modality therapy for primary bone lymphoma

Importance of combined-modality therapy for primary bone lymphoma

Author Baiocchi, Otavio Carvalho Guimarães Autor UNIFESP Google Scholar
Colleoni, Gisele Wally Braga Autor UNIFESP Google Scholar
Rodrigues, Celso Arrais Autor UNIFESP Google Scholar
Barton, D. Autor UNIFESP Google Scholar
Kerbauy, Fábio Rodrigues Autor UNIFESP Google Scholar
Garcia, R. J. Autor UNIFESP Google Scholar
Segreto, Roberto Araujo Autor UNIFESP Google Scholar
Alves, Antonio Correa Autor UNIFESP Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Primary bone lymphoma (PBL) is a rare entity and comprises about 5% of all extranodal non-Hodgkin's lymphomas (NHL) and 7% of all primary bone tumors. To date there is no consensus about the optimal treatment for PBL. We retrospectively reviewed all cases of PBL treated at Hospital São Paulo, Brazil, over a 10-year-period (January 1992-January 2002). Medical records of 7 patients with PBL were reviewed and information on age at diagnosis, sex, NHL clinical staging (CS), treatment and response to treatment were retrieved. Five patients (72%) received combined-modality therapy (CMT) and all of them are in complete remission (CR) with a median follow up of 19 months (ranging from 12 to 144 months). We conclude that PBL is a potentially curable malignancy and treatment should be undertaken in a multiprofessional approach, in order to provide the best support which probably has to include chemotherapy, radiotherapy and, for patients with IPI higher than 2, consolidation with stem-cell transplantation.
Keywords non-Hodgkin's lymphoma
bone lymphoma
treatment
prognosis
Language English
Date 2003-09-01
Published in Leukemia & Lymphoma. Abingdon: Taylor & Francis Ltd, v. 44, n. 10, p. 1837-1839, 2003.
ISSN 1042-8194 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 1837-1839
Origin http://dx.doi.org/10.1080/1042819031000110937
Access rights Closed access
Type Letter
Web of Science ID WOS:000185136500033
URI http://repositorio.unifesp.br/handle/11600/27403

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