Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein

Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein

Author Oliveira, Laerte Autor UNIFESP Google Scholar
Paiva, P. B. Google Scholar
Paiva, Antonio Cechelli de Mattos Autor UNIFESP Google Scholar
Vriend, Gerrit Google Scholar
Institution Katholieke Univ Nijmegan
Universidade Federal de São Paulo (UNIFESP)
Abstract Sequence entropy-variability plots based on alignments of very large numbers of sequences-can indicate the location in proteins of the main active site and modulator sites. in the previous article in this issue, we applied this observation to a series of well-studied proteins and concluded that it was possible to detect most of the residues with a known functional role. Here, we apply the method to rhodopsin-like G protein-coupled receptors. Our conclusion is that G protein binding is the main evolutionary constraint on these receptors, and that other ligands, such as agonists, act as modulators. the activation of the receptors can be described as a simple, two-step process, and the residues involved in signal transduction can be identified. (C) 2003 Wiley-Liss, Inc.
Keywords entropy-variability plots
G protein-coupled
receptors
recalcitrant residue positions
receptor evolution
Language English
Date 2003-09-01
Published in Proteins-structure Function and Genetics. New York: Wiley-liss, v. 52, n. 4, p. 553-560, 2003.
ISSN 0887-3585 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 553-560
Origin http://dx.doi.org/10.1002/prot.10489
Access rights Closed access
Type Article
Web of Science ID WOS:000184947400007
URI http://repositorio.unifesp.br/handle/11600/27382

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