Increased plasma homocysteine levels in shift working bus drivers

Increased plasma homocysteine levels in shift working bus drivers

Author Martins, PJF Autor UNIFESP Google Scholar
D'Almeida, V Autor UNIFESP Google Scholar
Vergani, N. Autor UNIFESP Google Scholar
Perez, ABA Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Previous studies have indicated an association between shift work and cardiovascular disease. There is also considerable epidemiological evidence that hyperhomocysteinemia is an independent risk factor for cardiovascular disorders.Aims: To analyse plasma homocysteine levels in shift work bus drivers, and to investigate possible relations with sleep parameters and other biochemical factors.Methods: Blood samples were collected from 30 male shift working long-haul bus drivers in a Brazilian sample and analysed for plasma levels of homocysteine, folic acid, vitamin B-12, and serum lipids. A group of 22 daytime workers, matched for age and body mass index served as controls. the incidence of mutations in the gene coding for methylene tetrahydrofolate, an enzyme which is related to hyperhomocysteinemia, was also assessed. Polysomnographic recordings were obtained from the target group.Results: Bus drivers showed significantly higher levels of plasma homocysteine than the control group (18.57 v 9.43 muM). Most of the other biochemical, behavioural, and molecular parameters did not differ between groups. Likewise, sleep parameters appeared to be within the normal range.Conclusions: the significantly increased plasma homocysteine levels in long-haul bus drivers did not appear to be secondary to other biochemical or behavioural problems in this group. These results suggest that hyperhomocysteinemia may be involved in the increased incidence of cardiovascular diseases observed in shift workers.
Language English
Date 2003-09-01
Published in Occupational and Environmental Medicine. London: British Med Journal Publ Group, v. 60, n. 9, p. 662-666, 2003.
ISSN 1351-0711 (Sherpa/Romeo, impact factor)
Publisher British Med Journal Publ Group
Extent 662-666
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000184904000008

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