Soluble Fas: A novel marker of inflammation in uremia

Soluble Fas: A novel marker of inflammation in uremia

Author Dalboni, Maria Aparecida Autor UNIFESP Google Scholar
Sardenberg, C. Google Scholar
Andreoli, M. C. Google Scholar
Watanabe, R. Google Scholar
Canziani, M. E. Google Scholar
Santos, BFC dos Google Scholar
Liangos, O. Google Scholar
Jaber, B. L. Google Scholar
Draibe, S. Google Scholar
Cendoroglo, M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Tufts Univ New England Med Ctr
Abstract Background: Inflammation has been associated with atherosclerotic cardiovascular disease (CVD) and anemia in patients with end-stage renal disease (ESRD). Recent studies have shown that serum levels of soluble Fas (sFas), an antiapoptotic and proinflammatory molecule, are elevated in patients with cardiac disease and patients with ESRD. We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation, anemia and CVD. Methods: the study included 25 ESRD patients (14 on hemodialysis, 11 on CAPD), 27 patients with chronic kidney disease (CKD; creatinine clearance <50 ml/min/1.73 m(2) ), and 14 normal control subjects. We measured serum levels of sFas, C-reactive protein (CRP), and albumin. We also investigated the association of serum sFas levels with the presence of CVD and with erythropoietin (EPO) dosage. Results: Levels of sFas were elevated in CKD and ESRD patients compared to controls. sFas levels correlated negatively with creatinine clearance. in the dialysis patients, we observed that sFas levels were higher among those with CVD. Serum levels of sFas correlated with serum levels of CRP (r=0.31; P =0.03), serum levels of albumin (r=-0.35, P =0.02), and EPO dosage (r=0.51; P =0.009). Conclusion: These results suggest that sFas may be a marker of inflammation in CKD and ESRD patients.
Keywords soluble Fas
C-reactive protein
albumin
inflammation
cardiovascular disease
dialysis
Language English
Date 2003-08-01
Published in Artificial Organs. Malden: Blackwell Publishing Inc, v. 27, n. 8, p. 687-691, 2003.
ISSN 0160-564X (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing Inc
Extent 687-691
Origin http://dx.doi.org/10.1046/j.1525-1594.2003.07274.x
Access rights Closed access
Type Article
Web of Science ID WOS:000184720100004
URI http://repositorio.unifesp.br/handle/11600/27358

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