Evaluation of acute administration of natural products with potential diuretic effects, in humans

Evaluation of acute administration of natural products with potential diuretic effects, in humans

Author Laranja, Sandra Maria Rodrigues Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract In order to evaluate the potential diuretic effect of two natural products, Elephantopus scaber and Alpinia speciosa, a trial administration was carried out in ten healthy volunteers and the effects compared to the those of a placebo. The substances were given on different days, with a seven day interval between doses. The amount of substance administered to the subjects was five times the usual dose i.e. 7.5 g/100 ml and 0.8 g/100 ml respectively. The following parameters parameteres were measured: urinary and plasma sodium, potassium, uric acid, calcium, phosphate, urea, creatinine. The subjects were also examined clinically and total urinary volume was assessed. The only significant finding (p < 0.05) was a slight diuresis with Alpinia speciosa, which also lowered the diastolic (p < 0.05) and systolic (p < 0.01) blood pressures. No effect on electrolytes or renal function parameters was observed, and this probably excludes any renal tubular or glomerular effect from these substances.
Keywords Natural products
diuretics
Elephantopus scaber
Alpinia speciosa
Language English
Date 1991-01-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 237-240, 1991.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 237-240
Origin http://dx.doi.org/10.1590/S0074-02761991000600053
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1991GN58900053
SciELO ID S0074-02761991000600053 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/273

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