Experimental paracoccidioidomycosis in dogs

Experimental paracoccidioidomycosis in dogs

Author Ono, Mario Augusto Autor UNIFESP Google Scholar
Kishima, M. O. Google Scholar
Itano, E. N. Google Scholar
Bracarense, Ana Paula Frederico Rodrigues Loureiro Autor UNIFESP Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Londrina (UEL)
Legislacao & Deontol
Dept Vet Prevent Med
Abstract The aim of this study was to evaluate the susceptibility of dogs to develop paracoccidioidomycosis by experimental infection. Puppies were inoculated with Paracoccidioides brasiliensis by an intravenous route and two out of four died 1 week postinoculation, showing, at histopathological analysis, granulomas in the lungs, spleen and liver. P. brasiliensis was isolated from these organs. the animals that survived the infection showed a strong reaction when skin was tested with gp43, a specific antigen of P. brasiliensis. These animals were killed at 1 and 5 months after infection, and no lesions, macroscopic or microscopic, were observed in the lungs, spleen or liver; furthermore no P. brasiliensis culture was obtained from these organs. These results suggest that dogs can develop paracoccidioidomycosis and reinforces the importance of this animal as a sensitive indicator of P. brasiliensis in the environment.
Keywords paracoccidioidomycosis
Paracoccidioides brasiliensis
experimental
dogs
fungus
Language English
Date 2003-06-01
Published in Medical Mycology. Abingdon: Taylor & Francis Ltd, v. 41, n. 3, p. 265-268, 2003.
ISSN 1369-3786 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 265-268
Origin http://dx.doi.org/10.1080/13693780310001597395
Access rights Closed access
Type Article
Web of Science ID WOS:000185320400012
URI http://repositorio.unifesp.br/handle/11600/27286

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