Immediate indocyanine green angiography and optical coherence tomography evaluation after photodynamic therapy for subfoveal choroidal neovascularization

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dc.contributor.author Costa, R. A.
dc.contributor.author Farah, M. E.
dc.contributor.author Cardillo, J. A.
dc.contributor.author Calucci, D.
dc.contributor.author Williams, G. A.
dc.date.accessioned 2016-01-24T12:33:47Z
dc.date.available 2016-01-24T12:33:47Z
dc.date.issued 2003-04-01
dc.identifier http://dx.doi.org/10.1097/00006982-200304000-00004
dc.identifier.citation Retina-the Journal of Retinal and Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 2, p. 159-165, 2003.
dc.identifier.issn 0275-004X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27202
dc.description.abstract Purpose: To better understand the mechanisms of action of photodynamic therapy (PDT) with verteporfin for subfoveal choroidal neovascularization (CNV), the authors evaluated the retinal and choroidal response immediately after treatment with serial optical coherence tomography (OCT) and indocyanine green angiography (ICGA).Methods: This study was a prospective, noncomparative case series. PDT was performed on nine eyes of nine consecutive patients who presented with subfoveal CNV due to age-related macular degeneration, and serial evaluation with OCT as well as ICGA was performed at 20-minute intervals for the first 2 hours and then at 1 week, 1 month, and 3 months.Results: in the first 2 hours after PDT, OCT showed an increase in the thickness of the retina in the treatment area due to fluid leakage from the neovascular complex as confirmed by ICGA. At 1 week, marked reduction of intraretinal/subretinal fluid was observed in all patients. Neovascular complex nonperfusion by ICGA was associated with some degree of choroidal hypoperfusion in the treatment area. Return of the foveal contour by OCT was optimal after 1 month of treatment. At 3 months, choroidal reperfusion by ICGA and recurrent intraretinal/subretinal fluid by OCT were observed.Conclusions: Serial OCT and ICGA evaluation after PDT suggests that the initial successful CNV nonperfusion as shown by fluorescein angiography at 1 week occurs by means of selective PDT damage to the lesion and/or reduced choroidal blood flow in the treatment area, thereby decreasing intraretinal/subretinal fluid and facilitating restoration of the retinal architecture. en
dc.format.extent 159-165
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Retina-the Journal of Retinal and Vitreous Diseases
dc.rights Acesso restrito
dc.subject age-realted macular degeneration en
dc.subject neovascular en
dc.subject complex en
dc.subject subretinal membrane en
dc.subject verteporfin en
dc.title Immediate indocyanine green angiography and optical coherence tomography evaluation after photodynamic therapy for subfoveal choroidal neovascularization en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Beaumont Eye Inst
dc.description.affiliation Universidade Federal de São Paulo, Dept Ophthalmol, Inst Visao, IPEPO, São Paulo, Brazil
dc.description.affiliation Beaumont Eye Inst, Associated Retinal Consultants, Royal Oak, MI USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ophthalmol, Inst Visao, IPEPO, São Paulo, Brazil
dc.identifier.doi 10.1097/00006982-200304000-00004
dc.description.source Web of Science
dc.identifier.wos WOS:000182898700004



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