Deficiency of muscle alpha-actinin-3 is compatible with high muscle performance

Deficiency of muscle alpha-actinin-3 is compatible with high muscle performance

Author Zanoteli, E. Google Scholar
Lotuffo, R. M. Google Scholar
Oliveira, ASB Google Scholar
Beggs, A. H. Google Scholar
Canovas, M. Google Scholar
Zatz, M. Google Scholar
Vainof, M. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Harvard Univ
Abstract Long-distance runners generally have a remarkably high proportion of slow type I fibers in their lower muscle groups. However, the transformation of type II fast fibers to slow type I fibers as a result of exercise has not been demonstrated clearly. We report the analysis of muscle type composition on m. vastus lateralis from six endurance athletes through the expression of fast, slow, and developmental myosin isoforms, and alpha-actinin-3 (ACTN3) protein. Only one among the marathon runners presented evident type I fiber predominance, and surprisingly, a second athlete showed a deficiency of ACTN3. the deficiency of ACTN3 in the muscle tissue of endurance athletes confirmed the redundancy of this protein for muscle function, even in muscles that are highly required.
Keywords muscle fiber type
marathon runners
myosin isoforms
Language English
Date 2003-02-01
Published in Journal of Molecular Neuroscience. Totowa: Humana Press Inc, v. 20, n. 1, p. 39-42, 2003.
ISSN 0895-8696 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 39-42
Access rights Closed access
Type Article
Web of Science ID WOS:000182000400005

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