Associations between cytokine gene polymorphisms and recurrent pregnancy loss

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dc.contributor.author Daher, S.
dc.contributor.author Shulzhenko, N.
dc.contributor.author Morgun, A.
dc.contributor.author Mattar, Rosiane [UNIFESP]
dc.contributor.author Rampim, G. F.
dc.contributor.author Camano, L.
dc.contributor.author DeLima, M. G.
dc.date.accessioned 2016-01-24T12:33:42Z
dc.date.available 2016-01-24T12:33:42Z
dc.date.issued 2003-02-01
dc.identifier http://dx.doi.org/10.1016/S0165-0378(02)00059-1
dc.identifier.citation Journal of Reproductive Immunology. Clare: Elsevier Sci Ireland Ltd, v. 58, n. 1, p. 69-77, 2003.
dc.identifier.issn 0165-0378
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27132
dc.description.abstract Since certain cytokines may play a role in unexplained recurrent pregnancy loss (RPL) and also some cytokine gene polymorphisms may affect the level of cytokine production, the aim of the present study was to investigate the relationship between RPL and polymorphisms of the genes coding for TNF-alpha (-308 G --> A), IL-10 (-1082 G --> A), IL-6 (-174 G --> C), and IFN-gamma (+874 A --> T). Genotyping was performed in 48 RPL women and 108 ethnically matched healthy individuals. in addition, we performed a meta-analysis encompassing the present results and those from studies on the association of TNF-alpha, IL-10 and IFN-gamma polymorphisms with RPL published in the literature until December 2001. the results showed: (1) no evidence of association with IL-6 gene polymorphisms; (2) significant associations, revealed by the meta-analysis, with the high cytokine production genotypes of IFN-gamma (+874 T/T: odds ratio (OR) = 1.92, P = 0.04) and IL-10 (-1082 G/G: OR = 1.75, P = 0.03), and a trend for association with the high TNF-alpha production genotypes -308 A/A and A/G (OR = 1.61; P = 0.18). We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. en
dc.format.extent 69-77
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Reproductive Immunology
dc.rights Acesso restrito
dc.subject pregnancy loss en
dc.subject cytokines en
dc.subject gene polymorphism en
dc.title Associations between cytokine gene polymorphisms and recurrent pregnancy loss en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, Div Immunogenet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, Div Immunogenet, São Paulo, Brazil
dc.identifier.doi 10.1016/S0165-0378(02)00059-1
dc.description.source Web of Science
dc.identifier.wos WOS:000181496800005



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