Nantenine alkaloid presents anticonvulsant effect on two classical animal models

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dc.contributor.author Ribeiro, R. A.
dc.contributor.author Leite, JR
dc.date.accessioned 2016-01-24T12:33:40Z
dc.date.available 2016-01-24T12:33:40Z
dc.date.issued 2003-01-01
dc.identifier http://dx.doi.org/10.1078/094471103322331557
dc.identifier.citation Phytomedicine. Jena: Urban & Fischer Verlag, v. 10, n. 6-7, p. 563-568, 2003.
dc.identifier.issn 0944-7113
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27101
dc.description.abstract The present study investigated the anticonvulsant and convulsant profiles of nantenine, an aporphine alkaloid found in several vegetal species. At lower doses (20-50 mg/kg, i.p) the alkaloid proved to be effective in inhibiting pentylenotetrazol- (PTZ 100 mg/kg, s.c) and maximal electroshock-induced seizures (80 mA, 50 pulses/s, 0.2 s), suggesting its potential as an anticonvulsant drug. However, at higher doses (greater than or equal to 75 mg/kg, i.p) a convulsant activity was observed. Comparing the present in vivo nantenine effects on seizures with previous in vitro biphasic action on Na+, K+-ATPase activity, the convulsant effect appears to be related to inhibition of these phosphatase at high doses whereas anticonvulsant effect, observed at low doses, seems attributable to its stimulation and the resultant decrease of Ca2+-influx into the cell. en
dc.format.extent 563-568
dc.language.iso eng
dc.publisher Urban & Fischer Verlag
dc.relation.ispartof Phytomedicine
dc.rights Acesso restrito
dc.subject nantenine en
dc.subject aporphine en
dc.subject alkaloid en
dc.subject anticonvulsant activity en
dc.subject convulsant activity en
dc.title Nantenine alkaloid presents anticonvulsant effect on two classical animal models en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023970 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023970 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023970 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023970 São Paulo, Brazil
dc.identifier.doi 10.1078/094471103322331557
dc.description.source Web of Science
dc.identifier.wos WOS:000185628600018



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