Nantenine alkaloid presents anticonvulsant effect on two classical animal models

Nantenine alkaloid presents anticonvulsant effect on two classical animal models

Author Ribeiro, R. A. Google Scholar
Leite, JR Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The present study investigated the anticonvulsant and convulsant profiles of nantenine, an aporphine alkaloid found in several vegetal species. At lower doses (20-50 mg/kg, i.p) the alkaloid proved to be effective in inhibiting pentylenotetrazol- (PTZ 100 mg/kg, s.c) and maximal electroshock-induced seizures (80 mA, 50 pulses/s, 0.2 s), suggesting its potential as an anticonvulsant drug. However, at higher doses (greater than or equal to 75 mg/kg, i.p) a convulsant activity was observed. Comparing the present in vivo nantenine effects on seizures with previous in vitro biphasic action on Na+, K+-ATPase activity, the convulsant effect appears to be related to inhibition of these phosphatase at high doses whereas anticonvulsant effect, observed at low doses, seems attributable to its stimulation and the resultant decrease of Ca2+-influx into the cell.
Keywords nantenine
aporphine
alkaloid
anticonvulsant activity
convulsant activity
Language English
Date 2003-01-01
Published in Phytomedicine. Jena: Urban & Fischer Verlag, v. 10, n. 6-7, p. 563-568, 2003.
ISSN 0944-7113 (Sherpa/Romeo, impact factor)
Publisher Urban & Fischer Verlag
Extent 563-568
Origin http://dx.doi.org/10.1078/094471103322331557
Access rights Closed access
Type Article
Web of Science ID WOS:000185628600018
URI http://repositorio.unifesp.br/handle/11600/27101

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