Effects of an oxalate load on urinary oxalate excretion in calcium stone formers

Effects of an oxalate load on urinary oxalate excretion in calcium stone formers

Autor Mendonca, CDG Google Scholar
Martini, L. A. Google Scholar
Baxmann, A. C. Google Scholar
Nishiura, J. L. Google Scholar
Cuppari, L. Google Scholar
Sigulem, D. M. Google Scholar
Heilberg, I. P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To investigate the oxalate intake and the effect of an oxalate load on urinary oxalate excretion in calcium stone-forming (CSF) patients.Design: Prospective study.Setting: University-affiliated outpatient Renal Lithiasis Unit.Patients and controls: Seventy (70) CSF and 41 healthy subjects (HS) collected a 24-hour urine sample and were submitted to a 3-day dietary record to determine mean oxalate (Ox), calcium (Ca) and vitamin C intake. Fifty-eight (58) CSF patients were randomly selected to receive milk (N = 28) or dark (N = 30) chocolate as an oxalate load.Intervention: Administration of either milk (94 mg Ox + 430 mg Ca) or dark chocolate (94 mg Ox + 26 mg Ca) for 3 days. A 24-hour urine sample was obtained before and after the load to determine calcium, oxalate, sodium, potassium, urea, and creatinine.Main outcome measure: Oxalate intake and excretion.Results: CSF patients presented mean Ox intake of 98 +/- 137 mg/d, similar to that of HS (108 +/- 139,mg/d).,Mean Ox and vitamin C intake was directly correlated with Ox excretion only in CSF. the consumption of dark,chocolate induced a significant increase in mean urinary Ox (36 +/- 14 versus 30 +/- 10 mg/24 hr) not observed in the milk chocolate group. Thus, a 2-fold increase in Ox intake,in this population of CSF patients produced a significant 20% increase in oxaluria, not observed when Ca was consumed simultaneously.Conclusion: the present study suggests that even small increases in Ox intake affect oxalate excretion,and the mitigation of urinary oxalate increase by Ca consumption reinforces that Ca and Ox intakes for CSF patients should be in balance. Further studies are necessary to assess whether or not a 20% increase in oxaluria will lead to a higher risk of stone formation. (C) 2003 by the National Kidney Foundation, Inc.
Idioma Inglês
Data de publicação 2003-01-01
Publicado em Journal of Renal Nutrition. Philadelphia: W B Saunders Co, v. 13, n. 1, p. 39-46, 2003.
ISSN 1051-2276 (Sherpa/Romeo, fator de impacto)
Publicador W B Saunders Co
Extensão 39-46
Fonte http://dx.doi.org/10.1053/jren.2003.50002
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000180841000007
Endereço permanente http://repositorio.unifesp.br/handle/11600/27099

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