Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice

Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice

Autor Silva, R. H. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Studies have suggested that opioid antagonists potentiate the anxiolytic effect but not the amnestic action of chlordiazepoxide (CDZ). We investigated the effects of naltrexone (NAL) on the anxiolytic and amnestic effects of CDZ in mice tested in the plus-maze discriminative avoidance task (DAT). Mice are conditioned to choose between two enclosed arms (one of which aversive) while avoiding the two open arms of the apparatus. This task measures memory (time spent in the aversive vs. time in the non-aversive enclosed arms) and anxiety (time spent in the open arms). Mice treated with saline (SAL) or 5 mg/kg NAL, and SAL or 2.5 mg/kg CDZ were submitted to DAT training. the test was performed 24 h later, without aversive stimuli. in the training, NAL + CDZ group showed higher percent time spent in the open arms than all the other groups. in the test, NAL + CDZ (but not SAL + CDZ) group showed higher percent time spent in the aversive enclosed arm than SAL + SAL and NAL + SAL groups. the data suggest that NAL potentiates the small decreases in anxiety and retention induced by a subeffective dose of CDZ. (C) 2002 Elsevier Science Inc. All rights reserved.
Palavra-chave plus-maze
naltrexone
chlordiazepoxide
avoidance learning
Idioma Inglês
Data de publicação 2002-12-27
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 72, n. 6, p. 721-730, 2002.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 721-730
Fonte http://dx.doi.org/10.1016/S0024-3205(02)02298-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000179845000009
Endereço permanente http://repositorio.unifesp.br/handle/11600/27074

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