Medulloblastoma in adults: a series from Brazil

Medulloblastoma in adults: a series from Brazil

Autor Malheiros, SMF Google Scholar
Franco, CMR Google Scholar
Stavale, J. N. Google Scholar
Santos, A. J. Google Scholar
Borges, LRR Google Scholar
Pelaez, M. P. Google Scholar
Ferraz, FAP Google Scholar
Gabbai, A. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We retrospectively reviewed 15 adult patients (11 males, median age 34 years; range 23-48) who had been treated and followed in our Institution since 1991 from the time of diagnosis until death or last follow-up in December 2001. Headache was the most frequent symptom (93%). the tumor was hemispheric in 11 patients. Complete resection was achieved in eight. CSF in 12 patients and craniospinal MRI in 6 did not show metastatic disease. Two patients refused adjuvant treatment and died with progressive disease. Thirteen patients received adjuvant craniospinal radiotherapy and 11 systemic chemotherapy. After initial treatment only 2 of the 13 patients relapsed in the posterior fossa. Recurrence was probably related to sub-optimal radiotherapy planning: inadequate low dose in the posterior fossa (37.5 Gy) and long delay in initiating treatment. Two of the 13 patients that received adjuvant treatment died: one from meningitis, and one from recurrent disease. Eleven patients remained alive, and disease-free with Karnofsky performance status ranging 80-100. the median overall survival was not reached after a median follow-up of 5.6 years (range 0.7-10.8 years). Estimated 1-, 5- and 10-year overall survival rates were 86.7%, 72.7%, and 72.7%, respectively. Adult medulloblastoma was predominant in males and the majority of patients had hemispheric tumors. Long-term survival was not uncommon. Although chemotherapy may be useful and well tolerated, radiotherapy remains the mainstay adjuvant treatment as suggested by our two recurrences associated with a delay or inadequate dose.
Palavra-chave medulloblastoma
surgery
chemotherapy
radiation therapy
adult
desmoplastic
Idioma Inglês
Data de publicação 2002-12-01
Publicado em Journal of Neuro-oncology. Dordrecht: Kluwer Academic Publ, v. 60, n. 3, p. 247-253, 2002.
ISSN 0167-594X (Sherpa/Romeo, fator de impacto)
Publicador Kluwer Academic Publ
Extensão 247-253
Fonte http://dx.doi.org/10.1023/A:1021178518361
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000179312400005
Endereço permanente http://repositorio.unifesp.br/handle/11600/27065

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