Protective effect of systemic treatment with cyclosporine A after global ischemia in rats

Protective effect of systemic treatment with cyclosporine A after global ischemia in rats

Autor Sinigaglia-Coimbra, R. Google Scholar
Cavalheiro, E. A. Google Scholar
Coimbra, C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Systemic administration of cyclosporine A (CsA) in single daily doses provides a powerful protection to the ischemic rat brain only to sites where the blood-brain barrier (BBB) is disrupted. This study was aimed at evaluating the effectiveness of prolonged treatment and multiple daily doses of systemic CsA following transient global ischemia in rats without BBB breakdown. Multiple daily doses selectively enhanced cell survival at 7-day recovery in regions displaying delayed neuronal death (DND). the effect was dose dependent, enhanced by prolonging the treatment or further fractionating daily doses, and not accompanied by drug-induced hypothermia. These results suggest that CsA-susceptible immune mediators of DND may be active during the first days following transient global ischemia. Conversely, postischemic hyperthermia may enhance and/or perpetuate similar mechanisms and trigger Alzheimer-like neurodegeneration, as recently reported. (C) 2002 Elsevier Science B.V. All rights reserved.
Assunto cerebral ischemia
delayed neuronal death (DND)
cyclosporine A
chronic neuronal death (CND)
Idioma Inglês
Data 2002-11-15
Publicado em Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 203, p. 273-276, 2002.
ISSN 0022-510X (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 273-276
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000179379600051

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