Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy

Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy

Autor Costa, R. A. Google Scholar
Scapucin, L. Google Scholar
Moracs, N. S. Google Scholar
Calucci, D. Google Scholar
Melo, L. A. Google Scholar
Cardillo, J. A. Google Scholar
Farah, M. E. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Consultores Retina & Associados
Resumo Purpose. To evaluate the potential benefit and complications of indocyanine green-mediated photothrombosis (IMP) in the management of patients with persistent central serous chorioretinopathy (CSC).Methods. Interventional noncomparative case series. Eleven patients with CSC presenting with persistent subretinal fluid in optical coherence tomography (OCT) four months after presentation and decrease in visual acuity (VA) were submitted to a single IMP session with 2 mg/kg body weight ICG and application of 5.6 W/cm(2) light at 8 10 nm. A continuous follow-up was provided with best-corrected ETDRS VA assessment, and angiographic and OCT documentation 72 hours before and at 2 days, 1 and 2 weeks, 1, 3, 6, and 12 months after treatment.Results. Pretreatment VA levels ranged from 20/32 - 1 to 20/100 (mean, 20/63 + 2 [logMAR equivalent, 0.460 +/- 0.155]); post treatment levels ranged from 20/25 - 2 to 20/20 (mean, 20/20 - 2 [logMAR equivalent, 0.038 +/- 0.048]). Ten out of eleven patients presented with VA levels of greater than or equal to20/25 2 weeks after treatment; the mean logMAR VA change of 0.345 at that time was statistically significant (p < 0.05, Friedman test). OCT disclosed resolution of persistent subretinal fluid in all eyes. No recurrence was observed after 12 months of follow-up. Complications included transient retinal whitening in two patients, and associated occlusion of retinal capillaries in one.Conclusions. Photothrombosis using low-intensity 810 nm light to direct laser energy continuously at the active leakage sites after intravenous ICG infusion induced rapid VA recovery in patients with persistent CSC; accordingly, restoration of the macular architecture was evidenced on OCT, and no recurrence was noted 12 months after IMP.
Palavra-chave hyperthermia
indocyanine green
laser optical coherence tomography
photodynamic therapy
thermotherapy
Idioma Inglês
Data de publicação 2002-11-01
Publicado em Current Eye Research. Lisse: Swets Zeitlinger Publishers, v. 25, n. 5, p. 287-297, 2002.
ISSN 0271-3683 (Sherpa/Romeo, fator de impacto)
Publicador Swets Zeitlinger Publishers
Extensão 287-297
Fonte http://dx.doi.org/10.1076/ceyr.25.5.287.13496
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000182203800005
Endereço permanente http://repositorio.unifesp.br/handle/11600/27033

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