Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study

Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study

Autor Andreatini, R. Google Scholar
Sartori, V. A. Google Scholar
Seabra, MLV Google Scholar
Leite, JR Google Scholar
Instituição Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of valepotriates. Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week washout, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): valepot-riates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and valepotriates groups showed a significant reduction in the psychic factor of HAM-A. the diazepam group also presented a significant reduction of the STAI-trait. Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted. Copyright (C) 2002 John Wiley Sons, Ltd.
Palavra-chave controlled clinical trial
diazepam
placebo
phytotherapy
Valeriana officinalis
Idioma Inglês
Data de publicação 2002-11-01
Publicado em Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 16, n. 7, p. 650-654, 2002.
ISSN 0951-418X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 650-654
Fonte http://dx.doi.org/10.1002/ptr.1027
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000179225800008
Endereço permanente http://repositorio.unifesp.br/handle/11600/27016

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