Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)

Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)

Autor Freire, Sonia Maria de Farias Google Scholar
Torres, Luce Maria Brandão Autor UNIFESP Google Scholar
Roque, Nidia Franca Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Instituição UFMA Departamento de Fisiologia
UFMA Departamento de Química
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Analgesic and anti-inflammatory activities of water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were investigated in rats and mice, and compared to the effects induced by Glutinol, a triterpene isolated by purification of EE. Oral adminsitration (p.o.) of either WE or EE(up to 2 g/Kg) did not alter the normal spontaneous activity of mice and rats. The sleeping time induced by sodium pentobarbital (50 mg/Kg, i.p.) was prolonged by 2 fold in mice pretreated with 0.5 g/Kg EE, p.o. Neither extract altered the tail flick response of mice in immersion test, but previous administration of EE (0.5 g/Kg, p.o.) reduced writhings induced by 0.8% acetic acid (0.1 ml/10 g, i.p.) in mice by 47% EE (0.5 and 1 g/Kg, p.o.) inhibited the paw edema induced by carrageenan in rats by respectively 46% and 58% after 2 h, being ineffective on the paw edema induced by dextran. No significant analgesic or anti-edema effects were detected in animals pretreated with WE (1 g/Kg, p.o.). Administration of Glutinol (30 mg/Kg, p.o.) reduced writhing induced by acetic acid in mice by 40% and the carrageenan induced paw edema in rats by 73%. The results indicate that the analgesic activity of S dulcis L. may be explained by explained by an anti-inflammatory activity probably related to the triterpene Glutinol.
Palavra-chave Scoparia dulcis L
analgesia
anti-inflammatory
medicinal plant
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 149-151, 1991.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 149-151
Fonte http://dx.doi.org/10.1590/S0074-02761991000600034
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1991GN58900034
SciELO S0074-02761991000600034 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/270

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