Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy

Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy

Autor Perosa, SR Google Scholar
Porcionatto, M. A. Google Scholar
Cukiert, A. Google Scholar
Martins, JRM Google Scholar
Passeroti, C. C. Google Scholar
Amado, D. Google Scholar
Matas, SLA Google Scholar
Nader, H. B. Google Scholar
Cavalheiro, E. A. Google Scholar
Leite, J. P. Google Scholar
Naffah-Mazzacoratti, M. G. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Brigadeiro Hosp
Universidade de São Paulo (USP)
Resumo Extracellular matrix proteoglycans (PGs) and glycosaminoglycans (GAGs) play a crucial role in cell differentiation and synaptogenesis by modulating neurite outgrowth. the chondroitin sulfate (CS)-rich PG, the receptor protein tyrosine phosphatase zeta/beta (RPTP zeta/beta), has been related to neural morphogenesis and axon guidance. Hippocampal sclerosis is the most frequent pathologic finding in patients with intractable mesial temporal lobe epilepsy (MTLE), which is associated with neuron loss, reactive gliosis, and mossy fiber sprouting. in the present study, we investigated the concentration of CS, heparan sulfate (HS) and hyaluronic acid (HA) in the hippocampus and temporal neocortex as well as RPTPzeta/beta expression in the hippocampus of patients with MTLE. Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of CS (224%; p=0.0109) and HA (146%; p=0.039). HS was instead similar to control values. No differences were found in the concentration of CS, HS, or HA in the temporal neocortex of epileptic patients when compared to control values. in contrast, RPTPzeta/beta immunoreactivity was induced in astrocytes of the inner molecular layer of the dentate gyrus of the sclerotic hippocampus. Because matrix compounds have been associated with tissue injury and repair, the present findings suggest that changes in PGs and GAGs might be related to damage-induced gliosis and neuronal reorganization in the hippocampus of WILE patients. (C) 2002 Elsevier Science Inc. All rights reserved.
Palavra-chave chondroitin sulfate
hyaluronic acid
heparan sulfate
temporal sclerosis
matrix components
RPTP zeta/beta
Idioma Inglês
Data de publicação 2002-09-15
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 58, n. 5, p. 509-516, 2002.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 509-516
Fonte http://dx.doi.org/10.1016/S0361-9230(02)00822-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000178477400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26981

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