Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy

Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy

Autor Murta, CGV Google Scholar
Moron, A. F. Google Scholar
Avila, MAP Google Scholar
Weiner, C. P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fed Univ Espirito Santo
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Maryland
Resumo Objective: To test the hypothesis the application of ductus venosus Doppler velocimetry may serve as a screening tool between 10 and 14 weeks' gestation for the detection of fetuses with chromosomal abnormalities. Methods: 372 consecutive fetuses were studied. Based on prior study, a chromosomal abnormality was suspected when either the nuchal translucency was above the 95th centile, or there was reversed or absent flow in the ductus venosus during atrial contraction. Sensitivity, specificity, and the negative and positive predictive values were calculated. Results: There were 29 chromosomally abnormal fetuses. of these 29 fetuses, ductus venosus blood flow during atrial contraction was either absent (n = 2) or reversed (n = 25) in 93.1 %. in the chromosomally normal fetuses (n = 343), only 6 (1.7%) had abnormal Doppler profiles in the ductus venosus (specificity = 98.3%, positive and negative predictive values = 81.8% and 99.4%, respectively). Conclusion: the Doppler waveform of the ductus venosus was at least equal to NT thickness measurement for the detection of chromosomal abnormalities. Copyright (C) 2002 S. Karger AG, Basel.
Palavra-chave Doppler velocimetry
ductus venosus
nuchal translucency
chromosomal abnormalities
Idioma Inglês
Data de publicação 2002-09-01
Publicado em Fetal Diagnosis and Therapy. Basel: Karger, v. 17, n. 5, p. 308-314, 2002.
ISSN 1015-3837 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 308-314
Fonte http://dx.doi.org/10.1159/000063185
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000177631000013
Endereço permanente http://repositorio.unifesp.br/handle/11600/26972

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