Trans fatty acids in maternal diet may impair lipid biosynthesis in mammary gland of lactating rats

Trans fatty acids in maternal diet may impair lipid biosynthesis in mammary gland of lactating rats

Author Assumpcao, R. P. Google Scholar
Santos, F. D. Google Scholar
Setta, C. L. Google Scholar
Barreto, G. F. Google Scholar
Matta, IEA Google Scholar
Estadella, D. Google Scholar
Azeredo, V. B. Google Scholar
Carmo, MGT do Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal Fluminense (UFF)
Abstract Although trans fatty acids are known to influence essential fatty acid (EFA) metabolism and serum levels of lipids and lipoproteins, little is known about their effects on the metabolism of mammary glands (MGs) during lactation. in this study, 5 groups of lactating Wistar rats were fed semisynthetic diets containing 7% soy oil (control); 7% partially hydrogenated vegetable oil (7% PHVO); 13% PHVO +7% soy oil (13% PHVO); 5% PHVO +2% soy oil (5% PHVO), and 3.5% PHVO +3.5% soy oil (3.5% PHVO). Dams were killed on the 12th day of lactation. Weight, lipid content (LC), in vivo lipogenesis rate (LR) and activity of the lipogenic (ATP-citrate lyase and malic) enzymes were evaluated in the MGs. Maternal food intake, weight gain, and total MG weight were not found to be significantly different between the groups. the groups with 13, 7 and 5% PHVO presented a lower (p < 0.05) LR in MGs when compared to controls, whereas MG LC was higher in the 7 and 13% groups than in controls. the observed decrease in MG lipogenesis was accompanied by a diminution (p < 0.05) in the activities of ATP-citrate lyase and malic enzymes. These data indicate a potential impairment of lipid metabolism in the MG by trans isomers in lactating rats. Copyright (C) 2002 S. Karger AG, Basel.
Keywords lactation
trans fatty acids
rat pup's growth
liver
mammary gland
lipogenesis
malic enzyme
ATP-citrate lyase enzyme
Language English
Date 2002-09-01
Published in Annals of Nutrition and Metabolism. Basel: Karger, v. 46, n. 5, p. 169-175, 2002.
ISSN 0250-6807 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 169-175
Origin http://dx.doi.org/10.1159/000065403
Access rights Closed access
Type Article
Web of Science ID WOS:000178862700002
URI http://repositorio.unifesp.br/handle/11600/26971

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