Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Autor Cairrao, MAR Google Scholar
Ribeiro, A. M. Google Scholar
Pizzo, A. B. Google Scholar
Fontana, ACK Google Scholar
Beleboni, R. O. Google Scholar
Coutinho-Netto, J. Google Scholar
Miranda, A. Google Scholar
Santos, W. F. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
Palavra-chave anticonvulsant
bicuculline
GABA
GABA uptake
Parawixia bistriata
pentilenetetrazole
picrotoxin
Scaptocosa raptoria
spider venom
rat synaptosomes
Idioma Inglês
Data de publicação 2002-09-01
Publicado em Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
ISSN 1388-0209 (Sherpa/Romeo, fator de impacto)
Publicador Swets Zeitlinger Publishers
Extensão 472-477
Fonte http://dx.doi.org/10.1076/phbi.40.6.472.8436
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000179940300014
Endereço permanente http://repositorio.unifesp.br/handle/11600/26969

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