Genetic diversity and HIV-1 incidence estimation among cocaine users in São Paulo, Brazil

Genetic diversity and HIV-1 incidence estimation among cocaine users in São Paulo, Brazil

Autor Turchi, M. D. Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Martelli, CMT Google Scholar
Sabino, E. C. Google Scholar
Silva, Wilson Pereira da Autor UNIFESP Google Scholar
Ferreira Filho, Olavo Autor UNIFESP Google Scholar
Laranjeira, Ronaldo Ramos Autor UNIFESP Google Scholar
Busch, M. P. Google Scholar
Castelo, Adauto Autor UNIFESP Google Scholar
Instituição Univ Calif San Francisco
Fundacao Prosangue
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Goias
Resumo We describe HIV-1 incidence and the prevalence of genetic subtypes among cocaine users in São Paulo, Brazil. A cross-sectional HIV-1 survey was carried out among 839 current cocaine users attending seven drug treatment units in the São Paulo metropolitan area from 1997 to 1998. HIV-1 subtyping was performed among 41 positive individuals using the heteroduplex mobility assay and DNA sequencing. Participants were mainly male (95.7%) with a history of previous imprisonment (54%), and the mean age was 26.9 years (SD = 7.2). the majority (64.4%) were current crack cocaine users, and 82.1% of the total participants were noninjectors. HIV-1 seroprevalence was 4.9% (95% confidence interval [CI], 3.6%-6.6%), and the incidence (estimated by the sensitive/less-sensitive immunoassay testing strategy) was 0.71% per year (95%.CI, 0.07-3.03). HIV-1 subtype B was predominant (90.3%), followed by subtype F. There was no statistically significant association between HIV-1 subtype and specific route of drug administration. Our incidence data show evidence of recent HIV-1 transmission among cocaine users, mainly among noninjectors. Detection of recently infected HIV-1 cases linked to genetic diversity analysis may provide baseline information for public health interventions in this sentinel group.
Palavra-chave HIV-1 incidence
HIV-1 prevalence
HIV-1 genetic subtyping
crack cocaine users
Idioma Inglês
Data de publicação 2002-08-15
Publicado em Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 5, p. 527-532, 2002.
ISSN 1525-4135 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 527-532
Fonte http://dx.doi.org/10.1097/01.QAI.0000018882.72916.60
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000177357800009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26947

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